Your Natural MELATONIN!
Melatonin is a hormone produced in your pineal gland according to your biological circadian rhythm. Call it the “night hormone” or “sleep hormone”. Melatonin is responsible for min. for your immunity, endurance, helps in regeneration and relaxation, generally supports the vital functions of your body.
When they touch you:
• arrhythmias and wakefulness
• problems falling asleep
• tiredness, daytime sleepiness
• distraction, lack of concentration,
• headache, irritability
• general malaise.
Consider whether your “sleep hormone” is in good hands!
MELATONIN – once and today… 😉
Melatonin – an organic chemical compound, a derivative of Tryptophan. In animals, it is a hormone synthesized mainly in the pineal gland. It coordinates the work of the parent biological clock in mammals, regulating circadian rhythms, including sleep and wakefulness.
Biosynthesis of melatonin occurs in pinealocytes. The starting product is Tryptophan, which, thanks to the action of hydroxylase, is converted into 5-hydroxytryptophan, which under the influence of 5-hydroxytryptophan decarboxylase is converted into 5-hydroxytryptamine (serotonin). Further synthesis consists of N-acetylation under the influence of N-acetyltransferase serotonin (its activity is subject to daily fluctuations) with the formation of N-acetylerotonin, which is o-methylated with the participation of 5-hydroxyindolo-O-methyltransferasis with the production of 5-methoxy-N-acetyltriptamine, or melatonin.
It is catabolized to kynuramin. As an example of one of the best known kynuramin Jaworek and others. n1-acetyl-N1-formlo-5-methoxycine (AFMK). These compounds, like Tryptophan, resemble the properties of melatonin.
The production of melatonin remains under the inhibitory influence of light. The body’s exposure during sleep to lighting causes a significant decrease in the synthesis and release of melatonin. Nerve impulses are transmitted by a nerve pathway that begins in the neurons of the retina and ends in the pericular spaces near the body of pinealocytes.
The presence of melatonin receptors has already been described in the fetal period.
Infants up to 12 weeks do not have a strictly defined circadian rhythm (their body hardly produces melatonin at all, the baby sleeps when it is eaten), only about 20 weeks there is a clear outline of this cycle. As the body ages, the pineal gland is instability, this reduces the amount of melatonin synthesized (which is why people aged 80 and over have trouble sleeping, often sleep in the daytime and wake up early in the morning).
It is currently sold in the form of over-the-counter tablets as a medicine (ATC N05CM17) to facilitate falling asleep in circadian arrhythmias in blind patients and in sleep disorders associated with time zone change (sudden time zone change syndrome). It is rapidly processed into two metabolites: 6-hydroxymelatonin and 6-sulfotoxymelatonin.
In addition to the pineal gland, melatonin is also synthesized by the retina and enterochromatophilic cells of the gastrointestinal tract. In the digestive system, it is responsible for slowing down digestive processes, although it stimulates the secretion of enzymes by the pancreas. In addition to regulating circadian rhythms, melatonin also has a beneficial effect on the immune system. It is also a powerful antioxidant.